The project at 350 Massachusetts Avenue is located at the corner of Massachusetts Avenue and Sydney Street, at the entrance to the University Park neighborhood. Originally constructed in the late 1990s, the building will be redesigned to accommodate laboratory (60%) and office (40%) spaces on floors two through five, retail on the ground floor, and a new mechanical penthouse, totaling 133,600 GSF. The design approach focuses on preserving the existing structure and brick veneer while upgrading the building to comply with updated energy codes and enhance both architectural detail and the pedestrian experience. The project is being redesigned to meet Cambridge’s resilience standards and targets LEED Gold certification, positioning it as a model for sustainable adaptive reuse.